This conference proceeding provides the compilation of all papers presented during the 2nd conference on Managing Digital Industry, Technology and Entrepreneurship (CoMDITE 2021) on 7th and 8th April 2021. This year, CoMDITE is held virtually with participations from local and international participants. The theme is Business Sustainability Through Digital Transformation. CoMDITE is mainly aimed to serve as a sharing platform that enables researchers, academics and practitioners to share the best practices, which have been produced through research, as well as to potentially propose the best strategy in utilizing digital transformation for business sustainability. All papers are presented according to the following seven tracks – (i) Big Data Analytics for Business, (ii) Digital Innovative and Education; (iii) Digital Marketing; (iv) Digital talent for Management; (v) Digital Technology for Business; (vi) Entrepreneurship and (vii) Strategic Management and Ecosystem Business.